Ionis partner Roche's sefaxersen cuts proteinuria 43.1% versus placebo in Phase 3 IgAN trial
Bitget2026/10/23 17:43- Ionis partner Roche reported sefaxersen reduced proteinuria 43.1% versus placebo at 37 weeks in the Phase 3 IMAgINATION trial for IgA nephropathy.
- The reduction was statistically significant (95% confidence interval: 32.5%-52%; P<0.0001), with consistent treatment effects across all prespecified subgroups.
- Sefaxersen, an investigational monthly injection designed for self-administration, was well tolerated, with no new safety signals.
- The blinded trial will continue to assess kidney function at week 105; Roche plans to share results with health authorities.
- The licensing agreement provides eligibility for regulatory and sales milestone payments, plus tiered royalties on sefaxersen net sales.
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